Scientific Programme

Times in the programme are:
Central European Summer Time (CEST): e.g. Oslo, Heidelberg, Aarhus, Umeå.

To find the equivalent time zone in your location, enter one of these locations, the CEST programme time and your city into the Time Zone Converter.

Participants attending the full event in Umeå, have the possibility to watch the live streaming in Aula Nordica, Universum, Umeå University. According to present regulations, the number of attendees is limited to 50 people, keeping social distancing.




Day 1 - Tuesday 22 September 2020

09:00-11:00 Nordic EMBL Partnership Steering Group Meeting
09:00-11:00 Young Investigator Workshop – Personal effectiveness: self-leadership and time management

Sarah Blackford, BioScience Careers, Germany
11:00-12:00 Nordic EMBL Administrator Meeting - Part I
12:00-12:30  Break
12:30-13:20 Welcome and Opening                           
12:30-12:40 Welcome by Hans Adolfsson on behalf of Umeå University
12:40-12:50 Welcome by Poul Nissen and update on the Partnership
12:50-13:00 Welcome by Oliver Billker on behalf of MIMS and technical details
13:00-13:20 Welcome and Updates from EMBL by Edith Heard


Session 1 - From simple to complex disease models

Chair: Oliver Billker, MIMS
13:30-14:05 Keynote lecture - Human Cell Atlas: Mapping the human body one cell at a time
Sarah Teichmann, Wellcome Sanger Institute, United Kingdom

The multimodal Platynereis cell type atlas
Detlev Arendt, EMBL Heidelberg

Investigating cell type-specific gene expression across developmental stages in the prenatal  human cerebral cortex
Mari Niemi, FIMM
14:35-14:50 Molecular views into cellular functions by in-cell cryo-electron tomography
Julia Mahamid, EMBL Heidelberg
14:50-15:20 Break/Poster Session I
15:20-15:25 NCMM Update by Janna Saarela

Centromere – a megadalton protein-DNA complex ensuring genomic integrity
Nikolina Sekulic, NCMM

Cryo-EM studies of membrane transporter systems in brain
Poul Nissen, DANDRITE

Cryo-EM structure of Helicobacter pylori urease with a novel inhibitor in the active site at 2.0 Å resolution
Eva Cunha, NCMM

Identification of the first receptor for the environmental signal ATP in bacteria
Sophie Tronnet, MIMS

Understanding cerebral malaria with in vitro 3D microvascular models
Maria Bernabeu, EMBL Barcelona

High-throughput in vivo screening identifies parasite genes determining parasite-host interactions in malaria infections
Ellen Bushell, MIMS

Brain slice model of alpha-synucleinopathies points to role of phosphorylation and strains in Parkinson’s disease and Multiple System Atrophy
Nanna Møller Jensen, DANDRITE

Mechanistic analysis in the omics era
Johan Henriksson, MIMS
16:45-17:15 Summary and Poster Session I continued



Day 2 - Wednesday 23 September 2020

10:00-12:00 Special event - Opening science to benefit scientists and society and Panel Discussion

Nonia Pariente, Editor-in-Chief, PLOS Biology, United Kingdom

Chair: Nonia Pariente
Panelists: Theodore Bloom, BMJ, United Kingdom; Ulrich Dirnagl, QUEST&Charité-Universitätsmedizin Berlin, Germany; Tony Ross-Hellauer, Graz University of Technology, Austria; Sophien Kamoun, The Sainsbury Laboratory, United Kingdom; Robert Kiley, Wellcome Trust, United Kingdom
12:00-13:00 Break
13:00-17:00 Session 2 - From microbes to mind

Chair: Maria Fällman, MIMS

Keynote lecture - Probing the interface of drugs and microbes
Nassos Typas, EMBL Heidelberg, Germany

Deciphering the evolutionary principles of antimicrobial peptide resistance
Balázs Papp, HCEMM-BRC

Microbes and the intestinal mucosal barrier
Björn O. Schröder, MIMS

RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection
Kemal Avican, MIMS

Identifying gut microbiome contributions to drug metabolism and toxicity
Michael Zimmerman, EMBL Heidelberg

Decoding bacterial cell wall genetics and environmental adaptation through omic-scale peptidoglycan profiling and network analysis
Felipe Cava, MIMS
14:40-15:10 Break/Poster Session II
15:10-15:15 MIMS Update by Oliver Billker

How does extreme genome compaction affect structure and function of an ancient conserved RNA-protein complex?
Jonas Barandun, MIMS

Structural basis for bacterial ribosome quality control by RqcH
Hiraku Takada, MIMS

Discovery of novel anti-chlamydial compounds by machine-learning-based predictive modelling
Magnus Ölander, MIMS

The glymphatic system – a brain-wide clearance system
Iben Lundgaard, Lund University

Whole tissue ex vivo imaging sheds light on tropism and neuroinvasion of tick-borne Flavivirus in mouse brain
Anna Överby Wernstedt, MIMS

Inhibited-state structure of human glycine transporter 1
Azadeh Shahsavar, DANDRITE

Severe sleep disorders are affected and modulated by immune function
Hanna Maria Ollila, FIMM
16:30-17:00 Summary and Poster Session II continued



Day 3 - Thursday 24 September 2020

14:00-18:00 Session 3 - From genetic associations to mechanisms

Chair: Anthony Mathelier, NCMM and Marieke Kuijjer, NCMM
14:00-14:05 FIMM Update by Mark Daly

Keynote lecture - Functional variations in the human genome: Lessons from the transcriptome
Tuuli Lappalainen, New York Genome Center & Columbia University, United States

Estimating the public health impact of genetic variants
Andrea Ganna, FIMM

Open Targets: from genetic associations to mechanisms of drug action – supporting therapeutic hypothesis generation and drug discovery
Ellen McDonagh, EMBL-EBI

Identifying genetic risk variants for Parkinson's disease
Mark Denham, DANDRITE

Orally administered SERCA inhibitor, Cyclopiazonic acid, slows neurodegeneration and increases life span in mouse prion-like spreading model of Parkinson’s disease

FIMM infrastructure for functional precision medicine
Sergey Kuznetsov, FIMM

Zebrafish larvae carrying a mutation in cacna1d display schizophrenia-like behaviours
Nancy Saana Banono, NCMM
15:40-16:10 Break/Poster Session III

Megadalton chromatin remodelers: common principles for genome regulation
Sebastian Eustermann, EMBL Heidelberg  

Genetic control of somatic mutation patterns in cancer genomes
Sebastian Waszak, NCMM     

Functional studies of genetic associations – three stories
Eiríkur Steingrímsson, Icelandic University

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments
Sarang Talwelkar, FIMM
17:00-17:05 Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of the gene regulatory program in cancers
Jaime Castro-Mondragon, NCMM
17:05-17:20 Effect of Cas9-fused DNA repair proteins on CRISPR editing outcomes
Emma Haapaniemi, NCMM CANCELLED
17:30-18:00 Summary and Poster Session III continued



Day 4 - Friday 25 September 2020


Session 4 - From biological to artificial neural networks

Chair: Poul Nissen, DANDRITE

Keynote lecture - From Biological to Artificial Neural Networks: The Case of Face Recognition
Winrich Freiwald, The Rockefeller University, United States

Learning action values in biological and artificial systems
Duda Kvitsiani, DANDRITE
14:50-15:05 Female copulation song: eavesdropping on the communication between nervous system and reproductive organs
Anne C. von Philipsborn, DANDRITE

Multiplexed axonal direction selectivity in retinal bipolar cells
Keisuke Yonehara, DANDRITE

GRASP imaging of auditory inputs to the basolateral amygdala
Mikhail Paveliev, DANDRITE

Engineering a dual-optical tool for spectrally distinct optogenetic excitation of neurons
Noemie Mermet-Joret, DANDRITE

Machine learning for microscopy image analysis
Anna Kreshuk, EMBL Heidelberg
15:45-15:55 Announcement of winners of the Science Art Competition 
15:55-16:45 Break/Poster Session IV
16:45-16:50 DANDRITE Update by Poul Nissen

Representation learning with deep neural networks to understand somatic mutagenesis in cancers
Esa Pitkänen, FIMM


Large-scale network models to understand gene regulation in healthy and diseased tissues
Marieke Kuijjer, NCMM

The power of multiomics
Wolfgang Huber, EMBL Heidelberg
17:35-17:50 Highlights and Closing remarks by Oliver Billker, MIMS



 Wednesday 30 September 2020

10:00-12:00 Nordic EMBL Administrators Meeting - Part II